Cells Escape an Operational Mitotic Checkpoint through a Stochastic Process
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چکیده
منابع مشابه
OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases
OTSSP167 was recently characterized as a potent inhibitor for maternal embryonic leucine zipper kinase (MELK) and is currently tested in Phase I clinical trials for solid tumors that have not responded to other treatment. Here we report that OTSSP167 abrogates the mitotic checkpoint at concentrations used to inhibit MELK. The abrogation is not recapitulated by RNAi mediated silencing of MELK in...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2018
ISSN: 0960-9822
DOI: 10.1016/j.cub.2017.11.031